Bioinformatics

Venn diagrams: a visualization nightmare!

I was recently reading a paper (a very inspiring read mapper for RNA-Seq!).  At some point the authors wanted to present the overlap between splice junctions detected by 4 RNA-Seq read mappers and choose to do so using the ubiquitous Venn diagram (see Fig. 1).  I spent a few minutes staring at this colorful mosaic...  without gaining much insight. Fig. 1:  Example of a four-way Venn diagram. Reproduced from figure 4b of Genome Biology, 14(3):R30, 2013. Which mappers overlapped most in [...]

By | 2016-11-08T09:30:16+00:00 October 20, 2014|Categories: Bioinformatics, Data Visualisation, Statistics|0 Comments

Gene symbols : the challenge

Almost certainly, one day, you'll have between your hands a list of outdated gene symbols. And you'll probably think that updating them is a straightforward task, but it's not that simple! Because there's the word 'bio' in bioinformatician, updating the gene symbols reminds me of the futile cycle. According to Wikipedia's definition, a futile cycle occurs when two metabolic pathways run simultaneously in opposite directions and have no overall effect other than to dissipate energy in the form of heat**.  Updating the [...]

By | 2016-11-08T09:30:17+00:00 September 29, 2014|Categories: Bioinformatics, Biology|0 Comments