{"id":2180,"date":"2016-04-13T13:59:16","date_gmt":"2016-04-13T17:59:16","guid":{"rendered":"http:\/\/bioinfo.iric.ca\/fr\/?page_id=2180"},"modified":"2025-07-10T21:48:13","modified_gmt":"2025-07-10T21:48:13","slug":"publications","status":"publish","type":"page","link":"https:\/\/bioinfo.iric.ca\/fr\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
\n

2025<\/h2>\n

DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes.<\/a>
\nKaya F, Bewicke-Copley F, Miettinen JJ, Casado P, Leddy E, Deniz \u00d6, Lavall\u00e9e VP, Philippe C, Zheng J, Grebien F, Khan N, Krizs\u00e1n S, Saad J, Nolin-Lapalme A, H\u00e9bert J, Lemieux S<\/strong>, Audemard E<\/strong>, Matthews J, Grantham M, Di Bella D, Wennerberg K, Parsons A, Gribben J, Cavenagh JD, Freeman SD, B\u00f6d\u00f6r C, Sauvageau G, Wang J, Llamas-Sillero P, Cazier JB, Taussig DC, Bonnet D, Cutillas PR, Heckman CA, Fitzgibbon J, Rouault-Pierre K, Rio-Machin A.
\nLeukemia. 2025 Jun;39(6):1526-1531. doi: 10.1038\/s41375-025-02593-8. Epub 2025 Apr 9.
\nPMID: 40204893 <\/p>\n

BRAF oncogenic mutants evade autoinhibition through a common mechanism. <\/a>
\nLavoie H, Jin T, Lajoie D, Decossas M, Gendron P<\/strong>, Wang B, Filandr F, Sahmi M, Hwa Jo C, Weber S, Arseneault G, Tripathy S, Beaulieu P, Schuetz DA, Schriemer DC, Marinier A, Rice WJ, Maisonneuve P, Therrien M.
\nScience. 2025 May 29;388(6750):eadp2742. doi: 10.1126\/science.adp2742. Epub 2025 May 29.
\nPMID: 40440367<\/p>\n

Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer. <\/a>
\nApavaloaei A, Zhao Q, Hesnard L, Cahuzac M, Durette C, Larouche JD, Hardy MP, Vincent K, Brochu S, Laverdure JP<\/strong>, Lanoix J, Courcelles M, Gendron P<\/strong>, Lajoie M, Ruiz Cuevas MV, Kina E, Perrault J, Humeau J, Ehx G, Lemieux S, Watson IR, Speiser DE, Bassani-Sternberg M, Thibault P, Perreault C.
\nNat Cancer. 2025 May 22. doi: 10.1038\/s43018-025-00979-2. Online ahead of print.
\nPMID: 40405018 <\/p>\n

IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia.<\/a>
\nM\u00e9tois A, Bordeleau ME, Theret L, Hajmirza A, Moujaber O, Spinella JF, Chagraoui J, Mayotte N, Boivin I, Audemard \u00c9<\/strong>, Aubert L, Lisi V, Khakipoor B, Farah A, Bonneil \u00c9, Robert A, Lippens J, Moraitis A, B\u00e9liveau F, Feghaly A<\/strong>, Boucher G<\/strong>, Marcotte R, Gendron P<\/strong>, Thibault P, Lemieux S<\/strong>, Richard-Carpentier G, Lavall\u00e9e VP, H\u00e9bert J, Roux PP, Sauvageau G.
\nBiomark Res. 2025 Apr 14;13(1):61. doi: 10.1186\/s40364-025-00769-z.
\nPMID: 40229904 <\/p>\n

2024<\/h2>\n

Long-term severe hypoxia adaptation induces non-canonical EMT and a novel Wilms Tumor 1 (WT1) isoform.<\/a>
\nQuenneville J, Feghaly A<\/strong>, Tual M, Thomas K, Major F, Gagnon E.
\nCancer Gene Ther. 2024 Aug;31(8):1237-1250. doi: 10.1038\/s41417-024-00795-3. Epub 2024 Jul 8.
\nPMID: 38977895<\/p>\n

Immunotherapeutic targeting of surfaceome heterogeneity in AML.<\/a>
\nBordeleau ME, Audemard \u00c9<\/strong>, M\u00e9tois A, Theret L, Lisi V, Farah A, Spinella JF, Chagraoui J, Moujaber O, Aubert L, Khakipoor B, Mallinger L, Boivin I, Mayotte N, Hajmirza A, Bonneil \u00c9, B\u00e9liveau F, Pfammatter S, Feghaly A<\/strong>, Boucher G<\/strong>, Gendron P<\/strong>, Thibault P, Barab\u00e9 F, Lemieux S<\/strong>, Richard-Carpentier G, H\u00e9bert J, Lavall\u00e9e VP, Roux PP, Sauvageau G.
\nCell Rep. 2024 Jun 4;43(6):114260. doi: 10.1016\/j.celrep.2024.114260.
\nPMID: 38838225<\/p>\n

Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia.<\/a>
\nNoronha N, Durette C, Cahuzac M, E Silva B, Courtois J, Humeau J, Sauvat A, Hardy MP, Vincent K, Laverdure JP<\/strong>, Lanoix J, Baron F, Thibault P, Perreault C, Ehx G.
\nLeukemia. 2024 May;38(5):1019-1031. doi: 10.1038\/s41375-024-02250-6. Epub 2024 Apr 16.
\nPMID: 38627586 <\/p>\n

Transposable elements regulate thymus development and function.<\/a>
\nLarouche JD, Laumont CM, Trofimov A, Vincent K, Hesnard L, Brochu S, C\u00f4t\u00e9 C, Humeau JF, Bonneil \u00c9, Lanoix J, Durette C, Gendron P<\/strong>, Laverdure JP<\/strong>, Richie ER, Lemieux S<\/strong>, Thibault P, Perreault C.
\nElife. 2024 Apr 18;12:RP91037. doi: 10.7554\/eLife.91037.
\nPMID: 38635416<\/p>\n

Breast cancer immunopeptidomes contain numerous shared tumor antigens.<\/a>
\nKina E, Laverdure JP<\/strong>, Durette C, Lanoix J, Courcelles M, Zhao Q, Apavaloaei A, Larouche JD, Hardy MP, Vincent K, Gendron P<\/strong>, Hesnard L, Th\u00e9riault C, Ruiz Cuevas MV, Ehx G, Thibault P, Perreault C.
\nJ Clin Invest. 2024 Jan 2;134(1):e166740. doi: 10.1172\/JCI166740.
\nPMID: 37906288<\/p>\n

CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax.<\/a>
\nGress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Th\u00e9ret L, Aubert L, Fatima F, Audemard \u00c9<\/strong>, Thibault P, Bonneil \u00c9, Chagraoui J, Laram\u00e9e L, Gendron P<\/strong>, Jouan L, Jammali S, Par\u00e9 B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barab\u00e9 F, Sauvageau G, Smith MA, H\u00e9bert J, Roux PP, Gruber TA, Lavall\u00e9e VP, Wilhelm BT, Cellot S.
\nBlood Adv. 2024 Jan 9;8(1):112-129. doi: 10.1182\/bloodadvances.2022008899.
\nPMID: 37729615<\/p>\n

2023<\/h2>\n

BamQuery: a proteogenomic tool to explore the immunopeptidome and prioritize actionable tumor antigens <\/a>
\nCuevas MVR, Hardy MP, Larouche JD, Apavaloaei A, Kina E, Vincent K, Gendron P<\/strong>, Laverdure JP<\/strong>, Durette C, Thibault P, Lemieux S<\/strong>, Perreault C, Ehx G.
\nGenome Biol. 2023 Aug 15;24(1):188. doi: 10.1186\/s13059-023-03029-1.
\nPMID: 37582761<\/p>\n

The eukaryotic translation initiation factor eIF4E reprograms alternative splicing.<\/a>
\nGhram M, Morris G, Culjkovic-Kraljacic B, Mars JC, Gendron P<\/strong>, Skrabanek L, Revuelta MV, Cerchietti L, Guzman ML, Borden KLB.
\nEMBO J. 2023 Apr 3;42(7):e110496. doi: 10.15252\/embj.2021110496.
\nPMID: 36843541<\/p>\n

2022<\/h2>\n

Two types of human TCR differentially regulate reactivity to self and non-self antigens.<\/a>
\nTrofimov A, Brouillard P, Larouche JD, S\u00e9guin J<\/strong>, Laverdure JP<\/strong>, Brasey A, Ehx G, Roy DC, Busque L, Lachance S, Lemieux S<\/strong>, Perreault C. \u00a0
\niScience. 2022 Aug 17;25(9):104968. doi: 10.1016\/j.isci.2022.104968.
\nPMID: 36111255<\/p>\n

Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers.<\/a>
\nApavaloaei A, Hesnard L, Hardy MP, Benabdallah B, Ehx G, Th\u00e9riault C, Laverdure JP<\/strong>, Durette C, Lanoix J, Courcelles M, Noronha N, Chauhan KD, Lemieux S<\/strong>, Beaus\u00e9jour C, Bhatia M, Thibault P, Perreault C.
\nCell Rep. 2022 Aug 16;40(7):111241. doi: 10.1016\/j.celrep.2022.111241.
\nPMID: 35977509<\/p>\n

Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia.<\/a>
\nLisi V, Blanchard \u00c8, Vladovsky M, Audemard E, Feghaly A, Lemieux S, <\/strong>H\u00e9bert J, Sauvageau G,<\/u> Lavall\u00e9e VP. \u00a0
\nBlood Adv.<\/strong> 2022 Jul 18: bloodadvances.2022007300. doi: 10.1182\/bloodadvances.2022007300.
\nPMID: 35849707<\/p>\n

Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability.<\/a>
\nCleyle J, Hardy MP, Minati R, Courcelles M, Durette C, Lanoix J, Laverdure JP<\/strong>, Vincent K, Perreault C, Thibault P.
\nMol Cell Proteomics. 2022 Mar 31:100228.
\nPMID: 35367648<\/p>\n

Monoallelic Heb\/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.<\/a>
\nVeiga DFT, Tremblay M, Gerby B, Herblot S, Haman A, Gendron P<\/strong>, Lemieux S<\/strong>, Z\u00fa\u00f1iga-Pfl\u00fccker JC, H\u00e9bert J, Cohen JP, Hoang T.
\nFront Immunol. 2022 Mar 24;13:867443.
\nPMID: 35401501<\/p>\n

UM171 expansion of cord blood improves donor availability and HLA matching for all patients, including minorities.<\/a>
\nDumont-Lagac\u00e9 M, Feghaly A<\/strong>, Meunier MC, Finney M, Van’t Hof W, Frenet EM, Sauvageau G, Cohen S.
\nTransplant Cell Ther. 2022 Mar 17:S2666-6367(22)01164-2.
\nPMID: 35311667<\/p>\n

Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.
\n<\/a>Krosl J, Bordeleau ME, Moison C, MacRae T, Boivin I, Mayotte N, Gracias D, Baccelli I, Lavall\u00e9e VP, Bisaillon R, Lehnertz B, Mendoza-Sanchez R, Ruel R, Bertomeu T, Coulombe-Huntington J, Boucher G<\/strong>, Noronha N, Pabst C, Tyers M, Gendron P<\/strong>, Lemieux S<\/strong>, Barab\u00e9 F, Marinier A, H\u00e9bert J, Sauvageau G.
\nBlood Adv. 2022 Jan 25;6(2):509-514.
\nPMID: 34731885<\/p>\n

2021<\/h2>\n

PSMB11 regulates gene expression in cortical thymic epithelial cells.<\/a>
\nApavaloaei A, Laverdure JP<\/strong>, Perreault
\nC. Cell Rep. 2021 Sep 7;36(10):109546.
\nPMID: 34496243<\/p>\n

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.<\/a>
\nEhx G, Larouche JD, Durette C, Laverdure JP<\/strong>, Hesnard L, Vincent K, Hardy MP, Th\u00e9riault C, Rulleau C, Lanoix J, Bonneil E, Feghaly A<\/strong>, Apavaloaei A, Noronha N, Laumont CM, Delisle JS, Vago L, H\u00e9bert J, Sauvageau G, Lemieux S<\/strong>, Thibault P, Perreault C.
\nImmunity. 2021 Apr 13;54(4):737-752.e10.
\nPMID: 33740418<\/p>\n

2020<\/h2>\n

NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.<\/a>
\nNourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, M\u00e9ant A, Aubert L, Grondin B, Gendron P<\/strong>, Chabot B, Bouvier M, Carreno S, Roux PP.
\nCell Rep. 2020 May 19;31(7):107660.
\nPMID: 32433969<\/p>\n

Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.<\/a>
\nLarouche JD, Trofimov A, Hesnard L, Ehx G, Zhao Q, Vincent K, Durette C, Gendron P<\/strong>, Laverdure JP,<\/strong> Bonneil \u00c9, C\u00f4t\u00e9 C, Lemieux S<\/strong>, Thibault P, Perreault C.
\nGenome Med. 2020 Apr 28;12(1):40.
\nPMID: 32345368<\/p>\n

Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer.<\/a>
\nZhao Q, Laverdure JP<\/strong>, Lanoix J, Durette C, C\u00f4t\u00e9 C, Bonneil \u00c9, Laumont CM, Gendron P<\/strong>, Vincent K, Courcelles M, Lemieux S<\/strong>, Millar DG, Ohashi PS, Thibault P, Perreault C.
\nCancer Immunol Res. 2020 Apr;8(4):544-555.
\nPMID: 32047025<\/p>\n

MAPDP: A Cloud-Based Computational Platform for Immunopeptidomics Analyses.<\/a>
\nCourcelles M, Durette C, Daouda T, Laverdure JP<\/strong>, Vincent K, Lemieux S<\/strong>, Perreault C, Thibault P.
\nJ Proteome Res. 2020 Apr 3;19(4):1873-1881.
\nPMID: 32108478<\/p>\n

Major multilevel molecular divergence between THP-1 cells from different biorepositories.<\/a>
\nNoronha N, Ehx G, Meunier MC, Laverdure JP<\/strong>, Th\u00e9riault C, Perreault C.
\nInt J Cancer. 2020 Mar 12.
\nPMID: 32163592<\/p>\n

High frequency of germline RUNX1 mutations in RUNX1 mutated AML patients.<\/a>
\nSimon L, Spinella JF, Yao CY, Lavall\u00e9e VP, Boivin I, Boucher G<\/strong>, Audemard E<\/strong>, Bordeleau ME, Lemieux S<\/strong>, Hebert J, Sauvageau G.
\nBlood. 2020 Feb 13. pii: blood.2019003357.
\nPMID: 32315381<\/p>\n

Genetic characterization of ABT-199 sensitivity in human AML.<\/a>
\nBisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavall\u00e9e VP, MacRae T, Mayotte N, Labelle C, Boucher G<\/strong>, Spinella JF, Boivin I, D’Angelo G, Lavall\u00e9e S, Marinier A, Lemieux S<\/strong>, H\u00e9bert J, Sauvageau G.
\nLeukemia. 2020 Jan;34(1):63-74.
\nPMID: 31300747<\/p>\n<\/div>\n

\n

2019<\/h2>\n<\/div>\n
\n

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.<\/a>
\nCardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laram\u00e9e L, Gendron P<\/strong>, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad \u00c9, Landry JR, Ma J, Humphries RK, Roux PP, H\u00e9bert J, Gruber TA, Wilhelm BT, Cellot S.
\nBlood Adv. 2019 Nov 12;3(21):3307-3321.
\nPMID: 31698461<\/p>\n

Cryptic recurrent ACIN1-NUTM1 fusions in non KMT2A-rearranged infant acute lymphoblastic leukemia.<\/a>
\nPincez T, Landry JR, Roussy M, Jouan L, Bilodeau M, Laram\u00e9e L, Couture F, Sinnett D, Gendron P<\/strong>, H\u00e9bert J, Oligny L, Rouette A, Tran TH, Wilhelm B, Bittencourt H, Cellot S
\nGenes Chromosomes Cancer. 2019 Sep 12.
\nPMID: 31515871<\/p>\n

IDH1 as a Cooperating Mutation in AML Arising in the Context of Shwachman-Diamond Syndrome.<\/a>
\nMourad S, Bilodeau M, Roussy M, Laram\u00e9e L, Boulianne L, Rouette A, Jouan L, Gendron P<\/strong>, Duval M, Teira P, H\u00e9bert J, Bittencourt H, Pastore Y, Landry JR, Cellot S.
\nFront Oncol. 2019 Aug 14;9:772. doi: 10.3389\/fonc.2019.00772. eCollection 2019.
\nPMID: 31475115<\/p>\n

Targeted variant detection using unaligned RNA-Seq reads.<\/a>
\nAudemard EO<\/strong>, Gendron P<\/strong>, Feghaly A<\/strong>, Lavall\u00e9e VP, H\u00e9bert J, Sauvageau G, Lemieux S.<\/strong>
\nLife Sci Alliance. 2019 Aug 19;2(4). pii: e201900336. doi: 10.26508\/lsa.201900336. Print 2019 Aug.
\nPMID: 31427380<\/p>\n

Genetic characterization of ABT-199 sensitivity in human AML.<\/a>
\nBisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavall\u00e9e VP, MacRae T, Mayotte N, Labelle C, Boucher<\/b> G<\/strong>, Spinella JF, Boivin I, D’Angelo G, Lavall\u00e9e S, Marinier A, Lemieux S<\/strong>, H\u00e9bert J, Sauvageau G.
\nLeukemia<\/span>. 2019 Jul 12. doi: 10.1038\/s41375-019-0485-x.
\nPMID: 31300747<\/p>\n

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.<\/a>
\nBaccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveill\u00e9 K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavall\u00e9e VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G<\/strong>, Roux PP, Lemieux S<\/strong>, Tyers M, Thibault P, H\u00e9bert J, Marinier A, Sauvageau G.
\nCancer Cell. 2019 Jul 8;36(1):84-99.e8. doi: 10.1016\/j.ccell.2019.06.003.
\nPMID: 31287994<\/p>\n

Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs.<\/a>
\nHardy MP, Audemard \u00c9<\/strong>, Migneault F, Feghaly A<\/strong>, Brochu S, Gendron P<\/strong>, Boilard \u00c9, Major F, Dieud\u00e9 M, H\u00e9bert MJ, Perreault C
\nSci Rep 2019-05-10;9(1):7203.
\nPMID: 31076589<\/p>\n

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.<\/a>
\nGarg S, Reyes-Palomares A, He L, Bergeron A, Lavall\u00e9e VP, Lemieux S<\/strong>, Gendron P<\/strong>, Rohde C, Xia J, Jagdhane P, M\u00fcller-Tidow C, Lipka DB, Imren S, Humphries RK, Waskow C, Vick B, Jeremias I, Richard-Carpentier G, H\u00e9bert J, Sauvageau G, Zaugg J, Barab\u00e9 F, Pabst C
\nBlood 2019-05-10.
\nPMID: 31076446<\/p>\n

Role of SUMOylation in differential ER\u03b1 transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.<\/a>
\nTraboulsi T, El Ezzy M, Dumeaux V, Audemard E<\/strong>, Mader S.
\nOncogene. 2019 Feb;38(7):1019-1037. doi: 10.1038\/s41388-018-0468-9. Epub 2018 Sep 6.
\nPMID: 30190545<\/p>\n

2018<\/h2>\n

Noncoding regions are the main source of targetable tumor-specific antigens.<\/a>
\nLaumont CM, Vincent K, Hesnard L, Audemard \u00c9<\/strong>, Bonneil \u00c9, Laverdure JP<\/strong>, Gendron P<\/strong>, Courcelles M, Hardy MP, C\u00f4t\u00e9 C, Durette C, St-Pierre C, Benhammadi M, Lanoix J, Vobecky S, Haddad E, Lemieux S<\/strong>, Thibault P, Perreault C.
\nSci Transl Med. 2018 Dec 5;10(470). pii: eaau5516. doi: 10.1126\/scitranslmed.aau5516.
\nPubmed ID: 30518613<\/p>\n

HIV-1 employs multiple mechanisms to resist Cas9\/sgRNA targeting the viral primer binding site<\/a>
\nWang Z, Wang W, Cui YC, Pan Q, Zhu W, Gendron P<\/strong>, Guo F, Cen S, Witcher M, Liang C.
\nJ Virol. 2018 Aug 1. pii: JVI.01135-18. doi: 10.1128\/JVI.01135-18.
\nPubmed ID: 30068653<\/p>\n

NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy.<\/a>
\nRoussy M, Bilodeau M, Jouan L, Tibout P, Laram\u00e9e L, Lemyre E, L\u00e9veill\u00e9 F, Tihy F, Cardin S, Sauvageau C, Couture F, Louis I, Choblet A, Patey N, Gendron P<\/strong>, Duval M, Teira P, H\u00e9bert J, Wilhelm BT, Choi JK, Gruber TA, Bittencourt H, Cellot S
\nGenes Chromosomes Cancer. 2018.
\nPubmed ID: 29427526<\/p>\n

2017<\/h2>\n

Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus.<\/a>
\nDumont-Lagac\u00e9 M, Gerbe H, Daouda T, Laverdure JP<\/strong>, Brochu S, Lemieux S<\/strong>, Gagnon \u00c9, Perreault C.
\nFront Immunol. 2017 Dec 5;8:1717.
\nPubmed ID: 29259606<\/p>\n

Chemogenomic landscape of RUNX1-mutated AML reveals importance of RUNX1 allele dosage in genetics and glucocorticoid sensitivity.<\/a>
\nSimon L, Lavall\u00e9e VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G<\/strong>, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny YA, Lemieux S<\/strong>, Marinier A, H\u00e9bert J, Sauvageau G
\nClin. Cancer Res. 2017.
\nPubmed ID: 28855357<\/p>\n

UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis.<\/a>
\nAucagne R, Girard S, Mayotte N, Lehnertz B, Lopes-Paciencia S, Gendron P<\/strong>, Boucher G<\/strong>, Chagraoui J, Sauvageau G
\nFASEB J. 2017.
\nPubmed ID: 28754713<\/p>\n

MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets.<\/a>
\nLemieux S<\/strong>, Sargeant T, Laperri\u00e8re D, Ismail H, Boucher G<\/strong>, Rozendaal M, Lavall\u00e9e VP, Ashton-Beaucage D, Wilhelm B, H\u00e9bert J, Hilton DJ, Mader S, Sauvageau G.
\nNucleic Acids Res. 2017 May 4. doi: 10.1093\/nar\/gkx338
\nPMID: 28472340<\/p>\n

A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.<\/a>
\nBaccelli I, Krosl J, Boucher G<\/strong>, Boivin I, Lavall\u00e9e VP, H\u00e9bert J, Lemieux S<\/strong>, Marinier A, Sauvageau G.
\nBlood Cancer J. 2017 Feb 17;7(2):e529. doi: 10.1038\/bcj.2017.10.
\nPMID: 28211886<\/p>\n

2016<\/h2>\n

MHC class I-associated peptides derive from selective regions of the human genome.<\/a>
\nPearson H, Daouda T, Granados DP, Durette C, Bonneil E, Courcelles M, Rodenbrock A, Laverdure JP<\/strong>, C\u00f4t\u00e9 C, Mader S, Lemieux S<\/strong>, Thibault P, Perreault C.
\nJ Clin Invest. 2016
\nPMID: 27841757<\/p>\n

Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers.<\/a>
\nRouette A, Trofimov A, Haberl D, Boucher G<\/strong>, Lavall\u00e9e VP, D’Angelo G, H\u00e9bert J, Sauvageau G, Lemieux S<\/strong>, Perreault C
\nSci Rep. 2016 Sep 23;6:34019.
\nPMID: 27659694<\/p>\n

myCircos: Facilitating the Creation and Use of Circos Plots Online <\/a>
\nLabelle C, Boucher G<\/strong>, Lemieux S<\/strong>
\nBioRxiv 2016-05-10.<\/p>\n

CRISPR\/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape<\/a>
\nZhen Wang, Qinghua Pan, Patrick Gendron<\/strong>, Weijun Zhu, Fei Guo, Shan Cen, Mark A. Wainberg, Chen Liang
\nCell Reports 2016
\nPMID: 27068471<\/p>\n

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors. <\/a>
\nLavall\u00e9e VP, Krosl J, Lemieux S<\/strong>, Boucher G<\/strong>, Gendron P<\/strong>, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, H\u00e9bert J, Sauvageau G
\nBlood 2016-03-31.
\nPMID: 27034432<\/p>\n

RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature.<\/a>
\nLavall\u00e9e VP, Lemieux S<\/strong>, Boucher G<\/strong>, Gendron P<\/strong>, Boivin I, Armstrong RN, Sauvageau G, H\u00e9bert J
\nBlood 2016-03-11.
\nPMID: 26968532<\/p>\n

Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers.<\/a>
\nGranados DP, Rodenbrock A, Laverdure JP<\/strong>, C\u00f4t\u00e9 C, Caron-Lizotte O, Carli C, Pearson H, Janelle V, Durette C, Bonneil E, Roy DC, Delisle JS, Lemieux S<\/strong>, Thibault P, Perreault C
\n<\/strong>Leukemia 2016-02-09.
\nPMID: 26857467<\/p>\n

Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations.<\/a>
\nLavall\u00e9e VP, Lemieux S<\/strong>, Boucher G<\/strong>, Gendron P<\/strong>, Boivin I, Girard S, H\u00e9bert J, Sauvageau G
\n<\/strong>Leukemia 2016-02-09.
\nPMID: 26859078<\/p>\n

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.<\/a>
\nPabst C, Bergeron A, Lavall\u00e9e VP, Yeh J, Gendron P<\/strong>, Norddahl GL, Krosl J, Boivin I, Deneault E, Simard J, Imren S, Boucher G<\/strong>, Eppert K, Herold T, Bohlander SK, Humphries K, Lemieux S<\/strong>, H\u00e9bert J, Sauvageau G, Barab\u00e9 F
\nBlood 2016-02-01.
\nPMID: 26834243<\/p>\n

Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.<\/a>
\nLaumont CM, Daouda T, Laverdure JP<\/strong>, Bonneil \u00c9, Caron-Lizotte O, Hardy MP, Granados DP, Durette C, Lemieux S<\/strong>, Thibault P, Perreault C
\n<\/strong>Nat Commun 2016-01-01;7:10238.
\nPMID: 26728094<\/p>\n

2015<\/h2>\n

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.<\/a>
\nLavall\u00e9e VP, Baccelli I, Krosl J, Wilhelm B, Barab\u00e9 F, Gendron P<\/strong>, Boucher G<\/strong>, Lemieux S<\/strong>, Marinier A, Meloche S, H\u00e9bert J, Sauvageau G
\nNat. Genet. 2015-09-01;47(9):1030-7.
\nPMID: 26237430<\/p>\n

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations.<\/a>
\nLavall\u00e9e VP, Gendron P<\/strong>, Lemieux S<\/strong>, D’Angelo G, H\u00e9bert J, Sauvageau G
\nBlood 2015-01-01;125(1):140-3.
\nPMID: 25331116<\/p>\n

2014<\/h2>\n

Long non-coding RNA expression in normal and leukemic human blood samples: Towards the identification of novel biomarkers and hematopoietic regulators<\/a>
\nLehnertz B, Boucher G<\/strong>, Mallard W, Gendron P<\/strong>, Hebert J, Lemieux S<\/strong>, Rinn J, Sauvageau G
\nExp. Hematol. 2014-08-01;42(8 Suppl):S45.<\/p>\n

AML with EVI1 rearrangements are characterized by SF3B1 and IKZF1 mutations and distinct expression of MECOM isoforms.<\/a>
\nLavall\u00e9e VP, Boivin I, Armstrong RN, Lemieux S<\/strong>, Gendron P<\/strong>, Hebert J, Sauvageau G
\nExp. Hematol. 2014-08-01;42(8 Suppl):S44.
\nPMID: 25106277<\/p>\n

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation<\/a>
\nZahreddine HA, Culjkovic-Kraljacic B, Assouline S, Gendron P<\/b>, Romeo AA, Morris SJ, Cormack G, Jaquith JB, Cerchietti L, Cocolakis E, Amri A, Bergeron J, Leber B, Becker MW, Pei S, Jordan CT, Miller WH, Borden KL.
\nNature<\/span>. 2014 Jul 3;511(7507):90-3.
\nPMID: 24870236<\/p>\n

Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.<\/a>
\nGranados DP, Sriranganadane D, Daouda T, Zieger A, Laumont CM, Caron-Lizotte O, Boucher G<\/strong>, Hardy MP, Gendron P<\/strong>, C\u00f4t\u00e9 C, Lemieux S<\/strong>, Thibault P, Perreault C
\nNat Commun 2014-04-09;5:3600.
\nPMID: 24714562<\/p>\n

Identification of small molecules that support human leukemia stem cell activity ex vivo.<\/a>
\nPabst C, Krosl J, Fares I, Boucher G<\/strong>, Ruel R, Marinier A, Lemieux S<\/strong>, H\u00e9bert J, Sauvageau G
\n<\/strong>Nat. Methods 2014-04-01;11(4):436-42.
\nPMID: 24562423<\/p>\n

A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS\/MAPK Signaling in Drosophila.<\/a>
\nAshton-Beaucage D, Udell CM, Gendron P<\/strong>, Sahmi M, Lefran\u00e7ois M, Baril C, Guenier AS, Duchaine J, Lamarre D, Lemieux S<\/strong>, Therrien M
\n<\/strong>PLoS Biol. 2014-03-01;12(3):e1001809.
\nPMID: 24643257<\/p>\n

2013<\/h2>\n

Harnessing virtual machines to simplify next-generation DNA sequencing analysis.<\/a>
\nNocq J, Celton M, Gendron P<\/strong>, Lemieux S<\/strong>, Wilhelm BT
\n<\/strong>Bioinformatics 2013-09-01;29(17):2075-83.
\nPMID: 23786767<\/p>\n

The expanding roles of G\u03b2\u03b3 subunits in G protein-coupled receptor signaling and drug action.<\/a>
\nKhan SM, Sleno R, Gora S, Zylbergold P, Laverdure JP<\/b>, Labb\u00e9 JC, Miller GJ, H\u00e9bert TE.
\nPharmacol Rev<\/span>. 2013 Feb 13;65(2):545-77.
\nPMID:23406670<\/p>\n

The TGF-\u03b2-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells.<\/a>
\nDelisle JS, Giroux M, Boucher G<\/b>, Landry JR, Hardy MP, Lemieux S<\/strong>, Jones RG, Wilhelm BT, Perreault C.
\nGenes Immun<\/span>. 2013 Mar;14(2):115-26.
\nPMID: 23328844<\/p>\n

2012<\/h2>\n

MHC I-associated peptides preferentially derive from transcripts bearing miRNA response elements.<\/a>
\nGranados DP, Yahyaoui W, Laumont CM, Daouda T, Muratore-Schroeder TL, C\u00f4t\u00e9 C, Laverdure JP<\/strong>, Lemieux S<\/strong>, Thibault P, Perreault C
\n<\/strong>Blood 2012-06-28;119(26):e181-91.
\nPMID: 22438248<\/p>\n

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia.<\/a>
\nSimon C, Chagraoui J, Krosl J, Gendron P<\/strong>, Wilhelm B, Lemieux S<\/strong>, Boucher G<\/strong>, Chagnon P, Drouin S, Lambert R, Rondeau C, Bilodeau A, Lavall\u00e9e S, Sauvageau M, H\u00e9bert J, Sauvageau G
\n<\/strong>Genes Dev. 2012-04-01;26(7):651-6.
\nPMID: 22431509<\/p>\n

Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation.<\/a>
\nGuimont-Desrochers F, Boucher G<\/b>, Dong Z, Dupuis M, Veillette A, Lesage S.
\nBlood<\/span>. 2012 May 10;119(19):4349-57.
\nPMID: 22353997<\/p>\n

Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.<\/a>
\nTing SB, Deneault E, Hope K, Cellot S, Chagraoui J, Mayotte N, Dorn JF, Laverdure JP<\/b>, Harvey M, Hawkins ED, Russell SM, Maddox PS, Iscove NN, Sauvageau G.
\nBlood<\/span>. 2012 Mar 15;119(11):2510-22.
\nPMID: 22174158<\/p>\n

2011<\/h2>\n

The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.<\/a>
\nCaron E, Vincent K, Fortier MH, Laverdure JP<\/strong>, Bramoull\u00e9 A, Hardy MP, Voisin G, Roux PP, Lemieux S<\/strong>, Thibault P, Perreault C
\nMol. Syst. Biol. 2011-01-01;7:533.
\nPMID: 21952136<\/p>\n

RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.<\/a>
\nWilhelm BT, Briau M, Austin P, Faubert A, Boucher G<\/strong>, Chagnon P, Hope K, Girard S, Mayotte N, Landry JR, H\u00e9bert J, Sauvageau G.
\nBlood. 2011 Jan 13;117(2):e27-38.
\nPMID: 20980679<\/p>\n

2010<\/h2>\n

Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.<\/a>
\nFortier S, Bilodeau M, Macrae T, Laverdure JP<\/b>, Azcoitia V, Girard S, Chagraoui J, Ringuette N, H\u00e9bert J, Krosl J, Mayotte N, Sauvageau G.
\nPLoS Genet<\/span>. 2010 Dec 9;6(12):e1001241.
\nPMID: 21170304<\/p>\n

The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila.<\/a>
\nAshton-Beaucage D, Udell CM, Lavoie H, Baril C, Lefran\u00e7ois M, Chagnon P, Gendron P<\/b>, Caron-Lizotte O, Bonneil E, Thibault P, Therrien M.
\nCell<\/span>. 2010 Oct 15;143(2):251-62.
\nPMID: 20946983<\/p>\n

Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease.<\/a>
\nJouan L, Melan\u00e7on P, Rodrigue-Gervais IG, Raymond VA, Selliah S, Boucher G<\/b>, Bilodeau M, Grandvaux N, Lamarre D.
\nJ Hepatol<\/span>. 2010 Feb;52(2):167-75.
\nPMID: 20006398<\/p>\n

2009<\/h2>\n

Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1.<\/a>
\nBilodeau M, MacRae T, Gaboury L, Laverdure JP<\/b>, Hardy MP, Mayotte N, Paradis V, Harton S, Perreault C, Sauvageau G.
\nPLoS One<\/span>. 2009 Oct 19;4(10):e7500.
\nPMID: 19838297<\/p>\n

Identification of the Candida albicans Cap1p regulon.<\/a>
\nZnaidi S, Barker KS, Weber S, Alarco AM, Liu TT, Boucher G<\/b>, Rogers PD, Raymond M.
\nEukaryot Cell<\/span>. 2009 Jun;8(6):806-20.
\nPMID: 19395663<\/p>\n

A functional screen to identify novel effectors of hematopoietic stem cell activity.<\/a>
\nDeneault E, Cellot S, Faubert A, Laverdure JP<\/b>, Fr\u00e9chette M, Chagraoui J, Mayotte N, Sauvageau M, Ting SB, Sauvageau G.
\nCell<\/span>. 2009 Apr 17;137(2):369-79.
\nPMID: 19379700<\/p>\n

Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans.<\/a>
\nTrunk K, Gendron P<\/strong>, Nantel A, Lemieux S<\/strong>, Roemer T, Raymond M
\n<\/strong>Eukaryotic Cell 2009-05-01;8(5):756-67.
\nPMID: 19270112<\/p>\n<\/div>\n