2024
Immunotherapeutic targeting of surfaceome heterogeneity in AML.
Bordeleau ME, Audemard É, Métois A, Theret L, Lisi V, Farah A, Spinella JF, Chagraoui J, Moujaber O, Aubert L, Khakipoor B, Mallinger L, Boivin I, Mayotte N, Hajmirza A, Bonneil É, Béliveau F, Pfammatter S, Feghaly A, Boucher G, Gendron P, Thibault P, Barabé F, Lemieux S, Richard-Carpentier G, Hébert J, Lavallée VP, Roux PP, Sauvageau G.
Cell Rep. 2024 Jun 4;43(6):114260. doi: 10.1016/j.celrep.2024.114260.
PMID: 38838225
Transposable elements regulate thymus development and function.
Larouche JD, Laumont CM, Trofimov A, Vincent K, Hesnard L, Brochu S, Côté C, Humeau JF, Bonneil É, Lanoix J, Durette C, Gendron P, Laverdure JP, Richie ER, Lemieux S, Thibault P, Perreault C.
Elife. 2024 Apr 18;12:RP91037. doi: 10.7554/eLife.91037.
PMID: 38635416
Breast cancer immunopeptidomes contain numerous shared tumor antigens.
Kina E, Laverdure JP, Durette C, Lanoix J, Courcelles M, Zhao Q, Apavaloaei A, Larouche JD, Hardy MP, Vincent K, Gendron P, Hesnard L, Thériault C, Ruiz Cuevas MV, Ehx G, Thibault P, Perreault C.
J Clin Invest. 2024 Jan 2;134(1):e166740. doi: 10.1172/JCI166740.
PMID: 37906288
CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax.
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard É, Thibault P, Bonneil É, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S.
Blood Adv. 2024 Jan 9;8(1):112-129. doi: 10.1182/bloodadvances.2022008899.
PMID: 37729615
2023
BamQuery: a proteogenomic tool to explore the immunopeptidome and prioritize actionable tumor antigens
Cuevas MVR, Hardy MP, Larouche JD, Apavaloaei A, Kina E, Vincent K, Gendron P, Laverdure JP, Durette C, Thibault P, Lemieux S, Perreault C, Ehx G.
Genome Biol. 2023 Aug 15;24(1):188. doi: 10.1186/s13059-023-03029-1.
PMID: 37582761
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing.
Ghram M, Morris G, Culjkovic-Kraljacic B, Mars JC, Gendron P, Skrabanek L, Revuelta MV, Cerchietti L, Guzman ML, Borden KLB.
EMBO J. 2023 Apr 3;42(7):e110496. doi: 10.15252/embj.2021110496.
PMID: 36843541
2022
Two types of human TCR differentially regulate reactivity to self and non-self antigens.
Trofimov A, Brouillard P, Larouche JD, Séguin J, Laverdure JP, Brasey A, Ehx G, Roy DC, Busque L, Lachance S, Lemieux S, Perreault C.
iScience. 2022 Aug 17;25(9):104968. doi: 10.1016/j.isci.2022.104968.
PMID: 36111255
Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers.
Apavaloaei A, Hesnard L, Hardy MP, Benabdallah B, Ehx G, Thériault C, Laverdure JP, Durette C, Lanoix J, Courcelles M, Noronha N, Chauhan KD, Lemieux S, Beauséjour C, Bhatia M, Thibault P, Perreault C. Cell Rep. 2022 Aug 16;40(7):111241. doi: 10.1016/j.celrep.2022.111241.
PMID: 35977509
Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia.
Lisi V, Blanchard È, Vladovsky M, Audemard E, Feghaly A, Lemieux S, Hébert J, Sauvageau G, Lavallée VP.
Blood Adv. 2022 Jul 18: bloodadvances.2022007300. doi: 10.1182/bloodadvances.2022007300.
PMID: 35849707
Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability.
Cleyle J, Hardy MP, Minati R, Courcelles M, Durette C, Lanoix J, Laverdure JP, Vincent K, Perreault C, Thibault P.
Mol Cell Proteomics. 2022 Mar 31:100228.
PMID: 35367648
Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.
Veiga DFT, Tremblay M, Gerby B, Herblot S, Haman A, Gendron P, Lemieux S, Zúñiga-Pflücker JC, Hébert J, Cohen JP, Hoang T.
Front Immunol. 2022 Mar 24;13:867443.
PMID: 35401501
UM171 expansion of cord blood improves donor availability and HLA matching for all patients, including minorities.
Dumont-Lagacé M, Feghaly A, Meunier MC, Finney M, Van’t Hof W, Frenet EM, Sauvageau G, Cohen S.
Transplant Cell Ther. 2022 Mar 17:S2666-6367(22)01164-2.
PMID: 35311667
Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.
Krosl J, Bordeleau ME, Moison C, MacRae T, Boivin I, Mayotte N, Gracias D, Baccelli I, Lavallée VP, Bisaillon R, Lehnertz B, Mendoza-Sanchez R, Ruel R, Bertomeu T, Coulombe-Huntington J, Boucher G, Noronha N, Pabst C, Tyers M, Gendron P, Lemieux S, Barabé F, Marinier A, Hébert J, Sauvageau G.
Blood Adv. 2022 Jan 25;6(2):509-514.
PMID: 34731885
2021
PSMB11 regulates gene expression in cortical thymic epithelial cells.
Apavaloaei A, Laverdure JP, Perreault
C. Cell Rep. 2021 Sep 7;36(10):109546.
PMID: 34496243
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.
Ehx G, Larouche JD, Durette C, Laverdure JP, Hesnard L, Vincent K, Hardy MP, Thériault C, Rulleau C, Lanoix J, Bonneil E, Feghaly A, Apavaloaei A, Noronha N, Laumont CM, Delisle JS, Vago L, Hébert J, Sauvageau G, Lemieux S, Thibault P, Perreault C.
Immunity. 2021 Apr 13;54(4):737-752.e10.
PMID: 33740418
2020
NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.
Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Méant A, Aubert L, Grondin B, Gendron P, Chabot B, Bouvier M, Carreno S, Roux PP.
Cell Rep. 2020 May 19;31(7):107660.
PMID: 32433969
Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.
Larouche JD, Trofimov A, Hesnard L, Ehx G, Zhao Q, Vincent K, Durette C, Gendron P, Laverdure JP, Bonneil É, Côté C, Lemieux S, Thibault P, Perreault C.
Genome Med. 2020 Apr 28;12(1):40.
PMID: 32345368
Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer.
Zhao Q, Laverdure JP, Lanoix J, Durette C, Côté C, Bonneil É, Laumont CM, Gendron P, Vincent K, Courcelles M, Lemieux S, Millar DG, Ohashi PS, Thibault P, Perreault C.
Cancer Immunol Res. 2020 Apr;8(4):544-555.
PMID: 32047025
MAPDP: A Cloud-Based Computational Platform for Immunopeptidomics Analyses.
Courcelles M, Durette C, Daouda T, Laverdure JP, Vincent K, Lemieux S, Perreault C, Thibault P.
J Proteome Res. 2020 Apr 3;19(4):1873-1881.
PMID: 32108478
Major multilevel molecular divergence between THP-1 cells from different biorepositories.
Noronha N, Ehx G, Meunier MC, Laverdure JP, Thériault C, Perreault C.
Int J Cancer. 2020 Mar 12.
PMID: 32163592
High frequency of germline RUNX1 mutations in RUNX1 mutated AML patients.
Simon L, Spinella JF, Yao CY, Lavallée VP, Boivin I, Boucher G, Audemard E, Bordeleau ME, Lemieux S, Hebert J, Sauvageau G.
Blood. 2020 Feb 13. pii: blood.2019003357.
PMID: 32315381
Genetic characterization of ABT-199 sensitivity in human AML.
Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D’Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G.
Leukemia. 2020 Jan;34(1):63-74.
PMID: 31300747
2019
Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.
Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramée L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad É, Landry JR, Ma J, Humphries RK, Roux PP, Hébert J, Gruber TA, Wilhelm BT, Cellot S.
Blood Adv. 2019 Nov 12;3(21):3307-3321.
PMID: 31698461
Cryptic recurrent ACIN1-NUTM1 fusions in non KMT2A-rearranged infant acute lymphoblastic leukemia.
Pincez T, Landry JR, Roussy M, Jouan L, Bilodeau M, Laramée L, Couture F, Sinnett D, Gendron P, Hébert J, Oligny L, Rouette A, Tran TH, Wilhelm B, Bittencourt H, Cellot S
Genes Chromosomes Cancer. 2019 Sep 12.
PMID: 31515871
IDH1 as a Cooperating Mutation in AML Arising in the Context of Shwachman-Diamond Syndrome.
Mourad S, Bilodeau M, Roussy M, Laramée L, Boulianne L, Rouette A, Jouan L, Gendron P, Duval M, Teira P, Hébert J, Bittencourt H, Pastore Y, Landry JR, Cellot S.
Front Oncol. 2019 Aug 14;9:772. doi: 10.3389/fonc.2019.00772. eCollection 2019.
PMID: 31475115
Targeted variant detection using unaligned RNA-Seq reads.
Audemard EO, Gendron P, Feghaly A, Lavallée VP, Hébert J, Sauvageau G, Lemieux S.
Life Sci Alliance. 2019 Aug 19;2(4). pii: e201900336. doi: 10.26508/lsa.201900336. Print 2019 Aug.
PMID: 31427380
Genetic characterization of ABT-199 sensitivity in human AML.
Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D’Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G.
Leukemia. 2019 Jul 12. doi: 10.1038/s41375-019-0485-x.
PMID: 31300747
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.
Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G.
Cancer Cell. 2019 Jul 8;36(1):84-99.e8. doi: 10.1016/j.ccell.2019.06.003.
PMID: 31287994
Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs.
Hardy MP, Audemard É, Migneault F, Feghaly A, Brochu S, Gendron P, Boilard É, Major F, Dieudé M, Hébert MJ, Perreault C
Sci Rep 2019-05-10;9(1):7203.
PMID: 31076589
Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.
Garg S, Reyes-Palomares A, He L, Bergeron A, Lavallée VP, Lemieux S, Gendron P, Rohde C, Xia J, Jagdhane P, Müller-Tidow C, Lipka DB, Imren S, Humphries RK, Waskow C, Vick B, Jeremias I, Richard-Carpentier G, Hébert J, Sauvageau G, Zaugg J, Barabé F, Pabst C
Blood 2019-05-10.
PMID: 31076446
Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.
Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S.
Oncogene. 2019 Feb;38(7):1019-1037. doi: 10.1038/s41388-018-0468-9. Epub 2018 Sep 6.
PMID: 30190545
2018
Noncoding regions are the main source of targetable tumor-specific antigens.
Laumont CM, Vincent K, Hesnard L, Audemard É, Bonneil É, Laverdure JP, Gendron P, Courcelles M, Hardy MP, Côté C, Durette C, St-Pierre C, Benhammadi M, Lanoix J, Vobecky S, Haddad E, Lemieux S, Thibault P, Perreault C.
Sci Transl Med. 2018 Dec 5;10(470). pii: eaau5516. doi: 10.1126/scitranslmed.aau5516.
Pubmed ID: 30518613
HIV-1 employs multiple mechanisms to resist Cas9/sgRNA targeting the viral primer binding site
Wang Z, Wang W, Cui YC, Pan Q, Zhu W, Gendron P, Guo F, Cen S, Witcher M, Liang C.
J Virol. 2018 Aug 1. pii: JVI.01135-18. doi: 10.1128/JVI.01135-18.
Pubmed ID: 30068653
NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy.
Roussy M, Bilodeau M, Jouan L, Tibout P, Laramée L, Lemyre E, Léveillé F, Tihy F, Cardin S, Sauvageau C, Couture F, Louis I, Choblet A, Patey N, Gendron P, Duval M, Teira P, Hébert J, Wilhelm BT, Choi JK, Gruber TA, Bittencourt H, Cellot S
Genes Chromosomes Cancer. 2018.
Pubmed ID: 29427526
2017
Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus.
Dumont-Lagacé M, Gerbe H, Daouda T, Laverdure JP, Brochu S, Lemieux S, Gagnon É, Perreault C.
Front Immunol. 2017 Dec 5;8:1717.
Pubmed ID: 29259606
Chemogenomic landscape of RUNX1-mutated AML reveals importance of RUNX1 allele dosage in genetics and glucocorticoid sensitivity.
Simon L, Lavallée VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny YA, Lemieux S, Marinier A, Hébert J, Sauvageau G
Clin. Cancer Res. 2017.
Pubmed ID: 28855357
UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis.
Aucagne R, Girard S, Mayotte N, Lehnertz B, Lopes-Paciencia S, Gendron P, Boucher G, Chagraoui J, Sauvageau G
FASEB J. 2017.
Pubmed ID: 28754713
MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets.
Lemieux S, Sargeant T, Laperrière D, Ismail H, Boucher G, Rozendaal M, Lavallée VP, Ashton-Beaucage D, Wilhelm B, Hébert J, Hilton DJ, Mader S, Sauvageau G.
Nucleic Acids Res. 2017 May 4. doi: 10.1093/nar/gkx338
PMID: 28472340
A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.
Baccelli I, Krosl J, Boucher G, Boivin I, Lavallée VP, Hébert J, Lemieux S, Marinier A, Sauvageau G.
Blood Cancer J. 2017 Feb 17;7(2):e529. doi: 10.1038/bcj.2017.10.
PMID: 28211886
2016
MHC class I-associated peptides derive from selective regions of the human genome.
Pearson H, Daouda T, Granados DP, Durette C, Bonneil E, Courcelles M, Rodenbrock A, Laverdure JP, Côté C, Mader S, Lemieux S, Thibault P, Perreault C.
J Clin Invest. 2016
PMID: 27841757
Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers.
Rouette A, Trofimov A, Haberl D, Boucher G, Lavallée VP, D’Angelo G, Hébert J, Sauvageau G, Lemieux S, Perreault C
Sci Rep. 2016 Sep 23;6:34019.
PMID: 27659694
myCircos: Facilitating the Creation and Use of Circos Plots Online
Labelle C, Boucher G, Lemieux S
BioRxiv 2016-05-10.
CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape
Zhen Wang, Qinghua Pan, Patrick Gendron, Weijun Zhu, Fei Guo, Shan Cen, Mark A. Wainberg, Chen Liang
Cell Reports 2016
PMID: 27068471
Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.
Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G
Blood 2016-03-31.
PMID: 27034432
RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature.
Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Armstrong RN, Sauvageau G, Hébert J
Blood 2016-03-11.
PMID: 26968532
Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers.
Granados DP, Rodenbrock A, Laverdure JP, Côté C, Caron-Lizotte O, Carli C, Pearson H, Janelle V, Durette C, Bonneil E, Roy DC, Delisle JS, Lemieux S, Thibault P, Perreault C
Leukemia 2016-02-09.
PMID: 26857467
Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations.
Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Girard S, Hébert J, Sauvageau G
Leukemia 2016-02-09.
PMID: 26859078
GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.
Pabst C, Bergeron A, Lavallée VP, Yeh J, Gendron P, Norddahl GL, Krosl J, Boivin I, Deneault E, Simard J, Imren S, Boucher G, Eppert K, Herold T, Bohlander SK, Humphries K, Lemieux S, Hébert J, Sauvageau G, Barabé F
Blood 2016-02-01.
PMID: 26834243
Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.
Laumont CM, Daouda T, Laverdure JP, Bonneil É, Caron-Lizotte O, Hardy MP, Granados DP, Durette C, Lemieux S, Thibault P, Perreault C
Nat Commun 2016-01-01;7:10238.
PMID: 26728094
2015
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.
Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G
Nat. Genet. 2015-09-01;47(9):1030-7.
PMID: 26237430
EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations.
Lavallée VP, Gendron P, Lemieux S, D’Angelo G, Hébert J, Sauvageau G
Blood 2015-01-01;125(1):140-3.
PMID: 25331116
2014
Long non-coding RNA expression in normal and leukemic human blood samples: Towards the identification of novel biomarkers and hematopoietic regulators
Lehnertz B, Boucher G, Mallard W, Gendron P, Hebert J, Lemieux S, Rinn J, Sauvageau G
Exp. Hematol. 2014-08-01;42(8 Suppl):S45.
AML with EVI1 rearrangements are characterized by SF3B1 and IKZF1 mutations and distinct expression of MECOM isoforms.
Lavallée VP, Boivin I, Armstrong RN, Lemieux S, Gendron P, Hebert J, Sauvageau G
Exp. Hematol. 2014-08-01;42(8 Suppl):S44.
PMID: 25106277
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation
Zahreddine HA, Culjkovic-Kraljacic B, Assouline S, Gendron P, Romeo AA, Morris SJ, Cormack G, Jaquith JB, Cerchietti L, Cocolakis E, Amri A, Bergeron J, Leber B, Becker MW, Pei S, Jordan CT, Miller WH, Borden KL.
Nature. 2014 Jul 3;511(7507):90-3.
PMID: 24870236
Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.
Granados DP, Sriranganadane D, Daouda T, Zieger A, Laumont CM, Caron-Lizotte O, Boucher G, Hardy MP, Gendron P, Côté C, Lemieux S, Thibault P, Perreault C
Nat Commun 2014-04-09;5:3600.
PMID: 24714562
Identification of small molecules that support human leukemia stem cell activity ex vivo.
Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G
Nat. Methods 2014-04-01;11(4):436-42.
PMID: 24562423
A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila.
Ashton-Beaucage D, Udell CM, Gendron P, Sahmi M, Lefrançois M, Baril C, Guenier AS, Duchaine J, Lamarre D, Lemieux S, Therrien M
PLoS Biol. 2014-03-01;12(3):e1001809.
PMID: 24643257
2013
Harnessing virtual machines to simplify next-generation DNA sequencing analysis.
Nocq J, Celton M, Gendron P, Lemieux S, Wilhelm BT
Bioinformatics 2013-09-01;29(17):2075-83.
PMID: 23786767
The expanding roles of Gβγ subunits in G protein-coupled receptor signaling and drug action.
Khan SM, Sleno R, Gora S, Zylbergold P, Laverdure JP, Labbé JC, Miller GJ, Hébert TE.
Pharmacol Rev. 2013 Feb 13;65(2):545-77.
PMID:23406670
The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells.
Delisle JS, Giroux M, Boucher G, Landry JR, Hardy MP, Lemieux S, Jones RG, Wilhelm BT, Perreault C.
Genes Immun. 2013 Mar;14(2):115-26.
PMID: 23328844
2012
MHC I-associated peptides preferentially derive from transcripts bearing miRNA response elements.
Granados DP, Yahyaoui W, Laumont CM, Daouda T, Muratore-Schroeder TL, Côté C, Laverdure JP, Lemieux S, Thibault P, Perreault C
Blood 2012-06-28;119(26):e181-91.
PMID: 22438248
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia.
Simon C, Chagraoui J, Krosl J, Gendron P, Wilhelm B, Lemieux S, Boucher G, Chagnon P, Drouin S, Lambert R, Rondeau C, Bilodeau A, Lavallée S, Sauvageau M, Hébert J, Sauvageau G
Genes Dev. 2012-04-01;26(7):651-6.
PMID: 22431509
Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation.
Guimont-Desrochers F, Boucher G, Dong Z, Dupuis M, Veillette A, Lesage S.
Blood. 2012 May 10;119(19):4349-57.
PMID: 22353997
Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.
Ting SB, Deneault E, Hope K, Cellot S, Chagraoui J, Mayotte N, Dorn JF, Laverdure JP, Harvey M, Hawkins ED, Russell SM, Maddox PS, Iscove NN, Sauvageau G.
Blood. 2012 Mar 15;119(11):2510-22.
PMID: 22174158
2011
The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.
Caron E, Vincent K, Fortier MH, Laverdure JP, Bramoullé A, Hardy MP, Voisin G, Roux PP, Lemieux S, Thibault P, Perreault C
Mol. Syst. Biol. 2011-01-01;7:533.
PMID: 21952136
RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.
Wilhelm BT, Briau M, Austin P, Faubert A, Boucher G, Chagnon P, Hope K, Girard S, Mayotte N, Landry JR, Hébert J, Sauvageau G.
Blood. 2011 Jan 13;117(2):e27-38.
PMID: 20980679
2010
Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.
Fortier S, Bilodeau M, Macrae T, Laverdure JP, Azcoitia V, Girard S, Chagraoui J, Ringuette N, Hébert J, Krosl J, Mayotte N, Sauvageau G.
PLoS Genet. 2010 Dec 9;6(12):e1001241.
PMID: 21170304
The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila.
Ashton-Beaucage D, Udell CM, Lavoie H, Baril C, Lefrançois M, Chagnon P, Gendron P, Caron-Lizotte O, Bonneil E, Thibault P, Therrien M.
Cell. 2010 Oct 15;143(2):251-62.
PMID: 20946983
Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease.
Jouan L, Melançon P, Rodrigue-Gervais IG, Raymond VA, Selliah S, Boucher G, Bilodeau M, Grandvaux N, Lamarre D.
J Hepatol. 2010 Feb;52(2):167-75.
PMID: 20006398
2009
Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1.
Bilodeau M, MacRae T, Gaboury L, Laverdure JP, Hardy MP, Mayotte N, Paradis V, Harton S, Perreault C, Sauvageau G.
PLoS One. 2009 Oct 19;4(10):e7500.
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Identification of the Candida albicans Cap1p regulon.
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