Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia.
Lisi V, Blanchard È, Vladovsky M, Audemard E, Ferghaly A, Lemieux S, Hébert J, Sauvageau G, Lavallée VP.  Blood Adv. 2022 Jul 18: bloodadvances.2022007300. doi: 10.1182/bloodadvances.2022007300.
PMID: 35849707

Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability.
Cleyle J, Hardy MP, Minati R, Courcelles M, Durette C, Lanoix J, Laverdure JP, Vincent K, Perreault C, Thibault P.
Mol Cell Proteomics. 2022 Mar 31:100228.
PMID: 35367648

Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.
Veiga DFT, Tremblay M, Gerby B, Herblot S, Haman A, Gendron P, Lemieux S, Zúñiga-Pflücker JC, Hébert J, Cohen JP, Hoang T.
Front Immunol. 2022 Mar 24;13:867443.
PMID: 35401501

UM171 expansion of cord blood improves donor availability and HLA matching for all patients, including minorities.
Dumont-Lagacé M, Feghaly A, Meunier MC, Finney M, Van’t Hof W, Frenet EM, Sauvageau G, Cohen S.
Transplant Cell Ther. 2022 Mar 17:S2666-6367(22)01164-2.
PMID: 35311667

Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.
Krosl J, Bordeleau ME, Moison C, MacRae T, Boivin I, Mayotte N, Gracias D, Baccelli I, Lavallée VP, Bisaillon R, Lehnertz B, Mendoza-Sanchez R, Ruel R, Bertomeu T, Coulombe-Huntington J, Boucher G, Noronha N, Pabst C, Tyers M, Gendron P, Lemieux S, Barabé F, Marinier A, Hébert J, Sauvageau G.
Blood Adv. 2022 Jan 25;6(2):509-514.
PMID: 34731885


PSMB11 regulates gene expression in cortical thymic epithelial cells.
Apavaloaei A, Laverdure JP, Perreault
C. Cell Rep. 2021 Sep 7;36(10):109546.
PMID: 34496243

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.
Ehx G, Larouche JD, Durette C, Laverdure JP, Hesnard L, Vincent K, Hardy MP, Thériault C, Rulleau C, Lanoix J, Bonneil E, Feghaly A, Apavaloaei A, Noronha N, Laumont CM, Delisle JS, Vago L, Hébert J, Sauvageau G, Lemieux S, Thibault P, Perreault C.
Immunity. 2021 Apr 13;54(4):737-752.e10.
PMID: 33740418


NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.
Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Méant A, Aubert L, Grondin B, Gendron P, Chabot B, Bouvier M, Carreno S, Roux PP.
Cell Rep. 2020 May 19;31(7):107660.
PMID: 32433969

Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.
Larouche JD, Trofimov A, Hesnard L, Ehx G, Zhao Q, Vincent K, Durette C, Gendron P, Laverdure JP, Bonneil É, Côté C, Lemieux S, Thibault P, Perreault C.
Genome Med. 2020 Apr 28;12(1):40.
PMID: 32345368

Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer.
Zhao Q, Laverdure JP, Lanoix J, Durette C, Côté C, Bonneil É, Laumont CM, Gendron P, Vincent K, Courcelles M, Lemieux S, Millar DG, Ohashi PS, Thibault P, Perreault C.
Cancer Immunol Res. 2020 Apr;8(4):544-555.
PMID: 32047025

MAPDP: A Cloud-Based Computational Platform for Immunopeptidomics Analyses.
Courcelles M, Durette C, Daouda T, Laverdure JP, Vincent K, Lemieux S, Perreault C, Thibault P.
J Proteome Res. 2020 Apr 3;19(4):1873-1881.
PMID: 32108478

Major multilevel molecular divergence between THP-1 cells from different biorepositories.
Noronha N, Ehx G, Meunier MC, Laverdure JP, Thériault C, Perreault C.
Int J Cancer. 2020 Mar 12.
PMID: 32163592

High frequency of germline RUNX1 mutations in RUNX1 mutated AML patients.
Simon L, Spinella JF, Yao CY, Lavallée VP, Boivin I, Boucher G, Audemard E, Bordeleau ME, Lemieux S, Hebert J, Sauvageau G.
Blood. 2020 Feb 13. pii: blood.2019003357.
PMID: 32315381

Genetic characterization of ABT-199 sensitivity in human AML.
Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D’Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G.
Leukemia. 2020 Jan;34(1):63-74.
PMID: 31300747


Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.
Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramée L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad É, Landry JR, Ma J, Humphries RK, Roux PP, Hébert J, Gruber TA, Wilhelm BT, Cellot S.
Blood Adv. 2019 Nov 12;3(21):3307-3321.
PMID: 31698461

Cryptic recurrent ACIN1-NUTM1 fusions in non KMT2A-rearranged infant acute lymphoblastic leukemia.
Pincez T, Landry JR, Roussy M, Jouan L, Bilodeau M, Laramée L, Couture F, Sinnett D, Gendron P, Hébert J, Oligny L, Rouette A, Tran TH, Wilhelm B, Bittencourt H, Cellot S
Genes Chromosomes Cancer. 2019 Sep 12.
PMID: 31515871

IDH1 as a Cooperating Mutation in AML Arising in the Context of Shwachman-Diamond Syndrome.
Mourad S, Bilodeau M, Roussy M, Laramée L, Boulianne L, Rouette A, Jouan L, Gendron P, Duval M, Teira P, Hébert J, Bittencourt H, Pastore Y, Landry JR, Cellot S.
Front Oncol. 2019 Aug 14;9:772. doi: 10.3389/fonc.2019.00772. eCollection 2019.
PMID: 31475115

Targeted variant detection using unaligned RNA-Seq reads.
Audemard EO, Gendron P, Feghaly A, Lavallée VP, Hébert J, Sauvageau G, Lemieux S.
Life Sci Alliance. 2019 Aug 19;2(4). pii: e201900336. doi: 10.26508/lsa.201900336. Print 2019 Aug.
PMID: 31427380

Genetic characterization of ABT-199 sensitivity in human AML.
Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D’Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G.
Leukemia. 2019 Jul 12. doi: 10.1038/s41375-019-0485-x.
PMID: 31300747

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.
Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G.
Cancer Cell. 2019 Jul 8;36(1):84-99.e8. doi: 10.1016/j.ccell.2019.06.003.
PMID: 31287994

Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs.
Hardy MP, Audemard É, Migneault F, Feghaly A, Brochu S, Gendron P, Boilard É, Major F, Dieudé M, Hébert MJ, Perreault C
Sci Rep 2019-05-10;9(1):7203.
PMID: 31076589

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.
Garg S, Reyes-Palomares A, He L, Bergeron A, Lavallée VP, Lemieux S, Gendron P, Rohde C, Xia J, Jagdhane P, Müller-Tidow C, Lipka DB, Imren S, Humphries RK, Waskow C, Vick B, Jeremias I, Richard-Carpentier G, Hébert J, Sauvageau G, Zaugg J, Barabé F, Pabst C
Blood 2019-05-10.
PMID: 31076446

Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.
Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S.
Oncogene. 2019 Feb;38(7):1019-1037. doi: 10.1038/s41388-018-0468-9. Epub 2018 Sep 6.
PMID: 30190545


Noncoding regions are the main source of targetable tumor-specific antigens.
Laumont CM, Vincent K, Hesnard L, Audemard É, Bonneil É, Laverdure JP, Gendron P, Courcelles M, Hardy MP, Côté C, Durette C, St-Pierre C, Benhammadi M, Lanoix J, Vobecky S, Haddad E, Lemieux S, Thibault P, Perreault C.
Sci Transl Med. 2018 Dec 5;10(470). pii: eaau5516. doi: 10.1126/scitranslmed.aau5516.
Pubmed ID: 30518613

HIV-1 employs multiple mechanisms to resist Cas9/sgRNA targeting the viral primer binding site
Wang Z, Wang W, Cui YC, Pan Q, Zhu W, Gendron P, Guo F, Cen S, Witcher M, Liang C.
J Virol. 2018 Aug 1. pii: JVI.01135-18. doi: 10.1128/JVI.01135-18.
Pubmed ID: 30068653

NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy.
Roussy M, Bilodeau M, Jouan L, Tibout P, Laramée L, Lemyre E, Léveillé F, Tihy F, Cardin S, Sauvageau C, Couture F, Louis I, Choblet A, Patey N, Gendron P, Duval M, Teira P, Hébert J, Wilhelm BT, Choi JK, Gruber TA, Bittencourt H, Cellot S
Genes Chromosomes Cancer. 2018.
Pubmed ID: 29427526


Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus.
Dumont-Lagacé M, Gerbe H, Daouda T, Laverdure JP, Brochu S, Lemieux S, Gagnon É, Perreault C.
Front Immunol. 2017 Dec 5;8:1717.
Pubmed ID: 29259606

Chemogenomic landscape of RUNX1-mutated AML reveals importance of RUNX1 allele dosage in genetics and glucocorticoid sensitivity.
Simon L, Lavallée VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny YA, Lemieux S, Marinier A, Hébert J, Sauvageau G
Clin. Cancer Res. 2017.
Pubmed ID: 28855357

UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis.
Aucagne R, Girard S, Mayotte N, Lehnertz B, Lopes-Paciencia S, Gendron P, Boucher G, Chagraoui J, Sauvageau G
FASEB J. 2017.
Pubmed ID: 28754713

MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets.
Lemieux S, Sargeant T, Laperrière D, Ismail H, Boucher G, Rozendaal M, Lavallée VP, Ashton-Beaucage D, Wilhelm B, Hébert J, Hilton DJ, Mader S, Sauvageau G.
Nucleic Acids Res. 2017 May 4. doi: 10.1093/nar/gkx338
PMID: 28472340

A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.
Baccelli I, Krosl J, Boucher G, Boivin I, Lavallée VP, Hébert J, Lemieux S, Marinier A, Sauvageau G.
Blood Cancer J. 2017 Feb 17;7(2):e529. doi: 10.1038/bcj.2017.10.
PMID: 28211886


MHC class I-associated peptides derive from selective regions of the human genome.
Pearson H, Daouda T, Granados DP, Durette C, Bonneil E, Courcelles M, Rodenbrock A, Laverdure JP, Côté C, Mader S, Lemieux S, Thibault P, Perreault C.
J Clin Invest. 2016
PMID: 27841757

Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers.
Rouette A, Trofimov A, Haberl D, Boucher G, Lavallée VP, D’Angelo G, Hébert J, Sauvageau G, Lemieux S, Perreault C
Sci Rep. 2016 Sep 23;6:34019.
PMID: 27659694

myCircos: Facilitating the Creation and Use of Circos Plots Online
Labelle C, Boucher G, Lemieux S
BioRxiv 2016-05-10.

CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape
Zhen Wang, Qinghua Pan, Patrick Gendron, Weijun Zhu, Fei Guo, Shan Cen, Mark A. Wainberg, Chen Liang
Cell Reports 2016
PMID: 27068471

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors. 
Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G
Blood 2016-03-31.
PMID: 27034432

RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature.
Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Armstrong RN, Sauvageau G, Hébert J
Blood 2016-03-11.
PMID: 26968532

Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers.
Granados DP, Rodenbrock A, Laverdure JP, Côté C, Caron-Lizotte O, Carli C, Pearson H, Janelle V, Durette C, Bonneil E, Roy DC, Delisle JS, Lemieux S, Thibault P, Perreault C
Leukemia 2016-02-09.
PMID: 26857467

Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations.
Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Girard S, Hébert J, Sauvageau G
Leukemia 2016-02-09.
PMID: 26859078

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.
Pabst C, Bergeron A, Lavallée VP, Yeh J, Gendron P, Norddahl GL, Krosl J, Boivin I, Deneault E, Simard J, Imren S, Boucher G, Eppert K, Herold T, Bohlander SK, Humphries K, Lemieux S, Hébert J, Sauvageau G, Barabé F
Blood 2016-02-01.
PMID: 26834243

Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.
Laumont CM, Daouda T, Laverdure JP, Bonneil É, Caron-Lizotte O, Hardy MP, Granados DP, Durette C, Lemieux S, Thibault P, Perreault C
Nat Commun 2016-01-01;7:10238.
PMID: 26728094